During the beginning of the COVID pandemic, when hospitals were overwhelmed and personal protective equipment was in short supply, healthcare-associated infections (HAIs) significantly increased after declining for years. Now, as more people succumb to “pandemic fatigue,” many have seemingly become less cautious about getting sick and are abandoning preventative behaviors, such as wearing masks and social distancing. Hospitals are beginning to fill up again as the flu, COVID, RSV, and other infectious diseases spread. Now is a good time for hospitals and private practices to review infection prevention strategies and be prepared for whatever the future may bring. Here are five strategies to get you started: