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Important Risk and Safety Information for Gebauer’s Pain Ease® and Gebauer’s Ethyl Chloride®:

Do not spray in eyes. Over spraying may cause frostbite. Freezing may alter skin pigmentation. Use caution when using product on persons with poor circulation. The thawing process may be painful and freezing may lower resistance to infection and delay healing. If skin irritation develops, discontinue use. CAUTION: Federal law restricts this device to sale by or on the order of a licensed healthcare practitioner.

Gebauer’s Pain Ease Only:

Apply only to intact oral mucous membranes. Do not use on genital mucous membranes. Consult your pediatrician when using on children 4 years old and younger.

Gebauer’s Ethyl Chloride Only:

Published clinical trial results support the use in children 3 years of age and older. Ethyl chloride is FLAMMABLE and should never be used in the presence of an open flame or electrical cautery equipment. Use in a well-ventilated area. Intentional misuse by deliberately concentrating or inhaling the contents can be harmful or fatal. Do not spray in eyes. Over application of the product may lead to frostbite and/or altered skin pigmentation. Cutaneous sensitization may occur, but appears to be extremely rare. CAUTION: Federal law restricts this device to sale by or on the order of a licensed healthcare practitioner.

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The Benefits of Pain Ease For Intravenous Cannulation

By: Kathleen Orellana | On: October 13, 2026
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Peripheral intravenous (PIV) cannulation is one of the most common invasive procedures, providing direct access to the bloodstream for fluids, medications, blood products, and nutritional support. It’s also frequently used for blood draws.

Despite how routine it is, IV placement has a high failure rate, up to 35-50%, according to the National Institutes of Health.

The procedures can also be painful, particularly for patients with needle anxiety, which may cause them to move and reduce the chances of a successful first attempt. Providing the patient with a topical anesthetic, like Gebauer's Pain Ease® topical anesthetic skin refrigerant, can help ease discomfort and anxiety, making the process smoother for both patients and healthcare providers.

The Role of Gebauer's Pain Ease in Intravenous Cannulation

Reduces Needle Anxiety and Pain

Needle anxiety is common and can cause patients to move during cannulation, making the procedure more difficult and painful. Using Gebauer’s Pain Ease can help reduce this anxiety by temporarily numbing the skin within seconds, making the process quicker, less painful, and potentially lowering failure rates.

Evidence Supporting Pain Ease's Effectiveness

Research indicates that Pain Ease is highly effective in reducing pain during venipuncture and IV cannulation. In a study involving 100 adults, 78% of those who received Pain Ease reported less pain compared to previous blood draws. Additionally, 80% of patients expressed a willingness to use the spray in the future​​​​.

Pain Ease and Vasoconstriction

One concern with topical anesthetics is the potential for vasoconstriction, which can make cannulation more challenging. However, clinical evidence supports that Gebauer's Pain Ease does not cause vasoconstriction. Studies have shown that cannulation success rates are the same or higher with Pain Ease compared to placebo and does not influence the vessel diameter because it is topical only.

Safe for Aseptic Procedures

Pain Ease is safe for use in aseptic procedures. It has passed microbial examinations and will not introduce microorganisms to a site that has already been treated with an antiseptic. This makes it suitable for use in various medical settings, including hospitals and clinics​​​​.

Learn More About Gebauer’s Pain Ease

Effective intravenous cannulation requires a combination of anatomical knowledge, technical skill, and patient management. By incorporating best practices and utilizing tools like Gebauer's Pain Ease, healthcare providers can improve the success rate of cannulation, minimize patient discomfort, and enhance the overall patient experience. Pain Ease not only reduces pain and anxiety but also supports a smoother and more efficient procedure, benefiting both patients and medical professionals.