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Important Risk and Safety Information for Gebauer’s Pain Ease® and Gebauer’s Ethyl Chloride®:

Do not spray in eyes. Over spraying may cause frostbite. Freezing may alter skin pigmentation. Use caution when using product on persons with poor circulation. The thawing process may be painful and freezing may lower resistance to infection and delay healing. If skin irritation develops, discontinue use. CAUTION: Federal law restricts this device to sale by or on the order of a licensed healthcare practitioner.

Gebauer’s Pain Ease Only:

Apply only to intact oral mucous membranes. Do not use on genital mucous membranes. Consult your pediatrician when using on children 4 years old and younger.

Gebauer’s Ethyl Chloride Only:

Published clinical trial results support the use in children 3 years of age and older. Ethyl chloride is FLAMMABLE and should never be used in the presence of an open flame or electrical cautery equipment. Use in a well-ventilated area. Intentional misuse by deliberately concentrating or inhaling the contents can be harmful or fatal. Do not spray in eyes. Over application of the product may lead to frostbite and/or altered skin pigmentation. Cutaneous sensitization may occur, but appears to be extremely rare. CAUTION: Federal law restricts this device to sale by or on the order of a licensed healthcare practitioner.

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Cryo Professional Versus Liquid Nitrogen: What Clinicians Should Know

By: Kathleen Orellana | On: March 16, 2026
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Is liquid nitrogen or Cryo Professional portable cryosurgical system the best way for clinicians to treat benign lesions or common dermatologic issues?

The first consideration for any primary care practice, urgent care, or mobile clinic is choosing a treatment solution that delivers the best clinical outcomes.

Since time, space, and cost are always considerations, the right solution must also be easy to use, portable, and affordable.

This means understanding how both solutions meet clinical efficacy, workflow, storage constraints, staff training, and operational overhead demands.

Clinical Efficacy and Portability in Practice

Studies indicate dimethyl ether and propane and liquid nitrogen have no clinically relevant differences in efficacy when treating benign lesions.

Cryo Professional meets the portability and safety needs of every practice because:

  • It uses a DMEP blend delivered via a handheld, self-contained aerosol with no need for tanks or cords
  • There is no need for refrigeration or special storage requirements, so practices can store it like any other Class II medical device
  • Treatment application is precise, quiet, and non-intimidating for children and nervous adult patients

Whether you’re treating in a clinic, a satellite office, or a standard outpatient suite, this system travels well and delivers consistent results.

A Practical Fit for Any Workflow

Tight appointment schedules of 15 to 30 minutes require effective treatments that don’t add time to those workflows. Cryo Professional integrates into workflows with:

  • Prep, treatment, and cleanup in under five minutes
  • Easy application by nurses and clinicians with minimal training
  • No warmup, calibration, or cooling downtime
  • Integrated spray control for adjustable flow
  • Single-use medical-grade applicator tips with consistent droplet delivery control for different lesion types and locations
  • Predictable surface temperature thresholds that avoid unnecessary dermal trauma

The size, storage, and movement of liquid nitrogen tanks make cryosurgery time-consuming and cumbersome at best. The spray attachments can intimidate patients and be just as imprecise as the use of cotton swabs for applications. Cryo Professional is highly portable via a familiar aerosol spray container and precise applicator attachments.

In most cases, clinicians can evaluate and treat a lesion during the same visit, without schedule disruptions or additional staff.

Safe for Patients, Smart for Staff

DMEP systems have a strong safety record and avoid the risks of liquid nitrogen or nitrous oxide cryosurgery. The Cryo Professional system uses dimethyl ether and propane making it safer to store and handle, especially in facilities that restrict gas storage. The aerosol spray-control design makes it ideal for use across a range of skin types, lesion sizes, patient ages, and clinical settings.

Affordability Without Cutting Corners

Cryosurgery systems must be affordable, effective, safe, portable, compliant, and easy to use. Unlike liquid nitrogen systems, Cryo Professional requires no tank refills, no cryogenic storage, and no dependency on specialty parts or outside servicing. Practices and clinics can easily store the Cryo Professional kit. This makes it a smart investment for:

  • Independent family medicine practices
  • Community clinics with limited budgets
  • Multi-site systems standardizing in-house dermatologic services
  • Urgent care settings managing high throughput

Compliance and Clinical Support for Providers

Although dermatology centers and hospitals use liquid nitrogen systems, they are usually delivered by an outsourced provider, making compliance more difficult. The Cryo Professional system is easy to use and includes training and support, helping clinicians maintain internal and external compliance standards and best practices.

Cryo Professional streamlines the care model without adding complexity, supporting improved clinical outcomes, repeatability, provider confidence, and patient trust.

Clinicians can resolve a wide range of wart and skin lesion issues during the visit, rather than outsourcing them. This all helps improve patient outcomes, provider workflows, and costs.

Learn more about how Gebauer's Cryo Professional portable cryosurgical system can transform cryosurgery in your practice and download a copy of our free guide.

IMPORTANT RISK AND SAFETY INFORMATION:

Cryo Professional is FLAMMABLE. Keep away from open flame and other potential ignition sources including diathermy or other medical equipment. Use in a well-ventilated area. Consult a pediatrician before use on patients 4 years old and younger. Do not use if uncertain of diagnosis or if there is a possibility of cancer, or on patients with cryoglobulinemia, circulatory issues, or using immunosuppressant medication. Do not spray cryogen directly on skin or when applicator tip is in contact with skin. Avoid eye contact. Use only as a system with the supplied applicators. Freezing may alter skin pigmentation. Avoid freezing of peripheral arteries. Carefully read instructions for use prior to using this product. CAUTION: Federal law restricts this device to sale by and on the order of a licensed healthcare practitioner.