Berberich FR, Landman Z.

Reducing immunization discomfort in 4-to-6- year old children: a randomized trial.
Pediatrics, 2009, August; 124(2); e203-209. Epub 2009 Jul 13.

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Clinical Research in the area of pain management is ongoing. Gebauer topical anesthetic skin refrigerants are reviewed in many such studies. The FDA has determined that each of the Gebauer family of topical anesthetic skin refrigerants is substantially equivalent (SE) to each other in terms of efficacy. Therefore, each clinical study is relevant to all Gebauer topical anesthetic skin refrigerants.

Important Risk and Safety Information for Gebauer's Pain Ease and Gebauer's Ethyl Chloride:

Published clinical trial results support the use in children three years of age and older. Do not spray in eyes. Over spraying may cause frostbite. Freezing may alter skin pigmentation. Use caution when using product on diabetics or persons with poor circulation. The thawing process may be painful and freezing may lower resistance to infection and delay healing. If skin irritation develops, discontinue use. Rx only.

Gebauer’s Pain Ease Only: Apply only to intact oral mucous membranes. Do not use on genital mucous membranes.

Gebauer’s Ethyl Chloride Only: Ethyl Chloride is FLAMMABLE and should never be used in the presence of an open flame, or electrical cautery equipment. Inhalation should be avoided as it may produce narcotic and general anesthetic effects, and may produce deep anesthesia or fatal coma or cardiac arrest. Cutaneous sensitization may occur, but appears to be extremely rare. Long term exposure may cause liver or kidney damage.